Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cariprazine hydrochloride (RGH188 hydrochloride) 是一种抗精神病药物,是一种 D3 和 D2 受体部分激动剂,Ki 分别为 0.09 nM 和 0.5 nM,对5-HT(1A)受体有一定亲和力。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 239 | 现货 | ||
10 mg | ¥ 389 | 现货 | ||
25 mg | ¥ 622 | 现货 | ||
50 mg | ¥ 970 | 现货 | ||
100 mg | ¥ 1,470 | 现货 | ||
500 mg | ¥ 3,670 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 413 | 现货 |
产品描述 | Cariprazine hydrochloride (RGH188 hydrochloride) is an antipsychotic drug, is a D3 and D2 receptor partial agonist((Ki of 0.085 nM and 0.49 nM, respectively) |
靶点活性 | D2 receptor:0.49 nM (Ki) , 5-HT1A receptor:2.6 nM (Ki), D3 receptor:0.085 nM (Ki) |
体内活性 | Cariprazine occupied D(2)/D(3) receptors in a dose-dependent and saturable manner, with the lowest dose occupying ~5% of receptors and the highest dose showing more than 90% occupancy. 5-HT(1A) receptor occupancy was considerably lower compared with D(2)/D(3) occupancy at the same doses, with a maximal value of ~30% for the raphe nuclei[1]. |
动物实验 | Three monkeys using the following PET radioligands: [(11)C]MNPA (an agonist at D(2) and D(3) receptors), [(11)C]raclopride (an antagonist at D(2) and D(3) receptors), and [(11)C]WAY-100635 (an antagonist at 5-HT(1A) receptors). During each experimental day, the first PET measurement was a baseline study, the second after a low dose of cariprazine, and the third after the administration of a high dose[1]. |
别名 | Cariprazine HCl, 盐酸卡利拉嗪, RGH188 hydrochloride |
分子量 | 463.87 |
分子式 | C21H33Cl3N4O |
CAS No. | 1083076-69-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: < 1mg/ml (insoluble), Sonication is recommended.
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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